CoolWWWSearch.SmartKiller (v1 and v2) is a new, very ugly variant of CoolWWWSearch.  When running, it will attempt (and probably succeed) to close every browser window you use to visit a most anti-spyware-sites.  It will even close Spybot-S&D and many other popular anti-spyware applications as well.

So if your copy of Spybot-S&D (or the anti-spyware application of your choice) closes a few seconds after starting, or your browser closes whenever you try to visit an anti-spyware site, make sure you check out the CWS.SmartKiller removal utility provided by Spybot Search & destroy on this page.